Dr Eyrun Floerecke Kjetland

Dr Eyrun Floerecke Kjetland

Person

Dr Eyrun Floerecke Kjetland

Telephone

+27 (0)31 260 4499

Email

e.f.kjetland@medisin.uio.no

Campus

Howard College

Research Interests

Schistosomiasis, sexually transmitted infections, HIV, reproductive tract health, female health, child health

Designation

Honorary Senior Lecturer

 Biosketch

The aim of my research has been to alleviate female suffering due to genital infections (www.brightresearch.org). In collaboration with more than 10 international senior scientists I am now running a project where we seek to show the effects of early intervention on genital morbidity and also on HIV incidence I have liaised with co-investigator Professor Taylor for research in rural schools in South Africa. Together, we have shown that it is feasible to do gynaecological investigations in teenagers, to ask very private questions in schools, to follow pupils many times and to get the blessings from their parents and teachers. In the current project, we have recruited from more than 60 schools, investigated 1800 young women, and have seen almost 800 for a second gynaecological investigation. We have demonstrated that it is possible to explore the afflicted populations, to run productive research projects on taboo issues, with high-tech equipment in rural, schistosomiasis endemic Africa. I have experience in working with grants from international donors and in five different countries. My experience has prepared me to lead projects for minors and adults in rural Africa.

List of Publications 
Co-authored international reports/publications
1.  WHO 2015. Female genital schistosomiasis – A pocket atlas for clinical health-care professionalshttp://apps.who.int/iris/bitstream/10665/180863/1/9789241509299_eng.pdf?ua=1 (verified 23.01.2016)
2.  WHO 2010. Report of an informal working group meeting on urogenital schistosomiasis and HIV transmissionhttp://whqlibdoc.who.int/hq/2010/WHO_HTM_NTD_PCT_2010.5_eng.pdf  (verified 30.10.2011).
3.  Report from the international workshop on schistosomiasis and reproductive health: 22-25 January 2008. Available at University of Copenhagen, Denmarkhttp://www.ivs.life.ku.dk/English/Sections/SPHD/Research/Research Projects/VIBE Project Female Genital Schistosomiasis.aspx (verified 30.10.2011).
Online resources: http://www.brightresearch.org  (research project website) 
Peer reviewed articles
1.    Randrianasolo BS, Jourdan PM, Ravoniarimbinina P, Ramarokoto CE, Rakotomanana F, Ravaoalimalala VE, Gundersen SG, Feldmeier H, Vennervald BJ, van Lieshout L, Roald B, Leutscher P, Kjetland EF, 2015. Gynecological Manifestations, Histopathological Findings, and Schistosoma-Specific Polymerase Chain Reaction Results Among Women With Schistosoma haematobium Infection: A Cross-sectional Study in Madagascar. J Infect Dis 212: 275-84.
2.    Kildemoes AO, Kjetland EF, Zulu SG, Taylor M, Vennervald BJ, 2015.Schistosoma haematobium infection and asymptomatic bacteriuria in young South African females. Acta Trop 144: 19-23.
3.    Holmen SD, Kleppa E, Lillebo K, Pillay P, van Lieshout L, Taylor M, Albregtsen F, Vennervald BJ, Onsrud M, Kjetland EF, 2015. The First Step Toward Diagnosing Female Genital Schistosomiasis by Computer Image Analysis. The American journal of tropical medicine and hygiene 93: 80-6.
4.    Kleppa E, Holmen SD, Lillebo K, Kjetland EF, Gundersen SG, Taylor M, Moodley P, Onsrud M, 2015. Cervical ectopy: associations with sexually transmitted infections and HIV. A cross-sectional study of high school students in rural South Africa. Sex Transm Infect 91: 124-9.
5.    Randjelovic A, Frønæs SG, Munsami M, Kvalsvig JD, Zulu SG, Gagai S, Maphumulo A, Sandvik L, Gundersen SG, Kjetland EF, Taylor M, 2015. A study of hurdles in mass treatment of schistosomiasis in KwaZulu-Natal, South Africa. South African Family Practice 57 57-61.
6.    Magaisa K, Taylor M, Kjetland EF, Naidoo PJ, 2015. A review of the control of schistosomiasis in South Africa. South African Journal of Science: 111 (11/12): 1-9
7.    Stecher CW, Kallestrup P, Kjetland EF, Vennervald B, Petersen E, 2015. Considering treatment of male genital schistosomiasis as a tool for future HIV prevention: a systematic review. Int J Public Health.
8.    Kjetland EF, Hegertun IE, Baay MF, Onsrud M, Ndhlovu PD, Taylor M, 2014. Genital schistosomiasis and its unacknowledged role on HIV transmission in the STD intervention studies. Int J STD AIDS 25: 705-15.
9.    Kjetland EF, Norseth HM, Taylor M, Lillebo K, Kleppa E, Holmen SD, Andebirhan A, Yohannes TH, Gundersen SG, Vennervald BJ, Bagratee J, Onsrud M, Leutscher PD, 2014. Classification of the lesions observed in female genital schistosomiasis. Int J Gynaecol Obstet 127: 227-8.
10.              Norseth HM, Ndhlovu PD, Kleppa E, Randrianasolo BS, Jourdan PM, Roald B, Holmen SD, Gundersen SG, Bagratee J, Onsrud M, Kjetland EF, 2014. The colposcopic atlas of schistosomiasis in the lower female genital tract based on studies in Malawi,Zimbabwe, Madagascar and South Africa. PLoS Negl Trop Dis 8: e3229.
11.              Kleppa E, Ramsuran V, Zulu S, Karlsen GH, Bere A, Passmore JA, Ndhlovu P, Lillebo K, Holmen SD, Onsrud M, Gundersen SG, Taylor M,Kjetland EF, Ndung’u T, 2014. Effect of female genital schistosomiasis and anti-schistosomal treatment on monocytes, CD4+ T-cells and CCR5 expression in the female genital tract. PLoS One 9: e98593.
12.              Kleppa E, Holmen SD, Lillebo K, Pillay P, Taylor M, Gundersen SG,Kjetland EF, Onsrud M, 2014. Re: Al-Baghdadi O, Samarasinghe A, Wissa I. 2014. Cervical schistosomiasis. Journal of Obstetrics and Gynaecology 34:206. J Obstet Gynaecol 34: 755-6.
13.              Pillay P, Taylor M, Zulu SG, Gundersen SG, Verweij JJ, Hoekstra P, Brienen EA, Kleppa E, Kjetland EF, van Lieshout L, 2014. Real-time polymerase chain reaction for detection of Schistosoma DNA in small-volume urine samples reflects focal distribution of urogenital Schistosomiasis in primary school girls in KwaZulu Natal, South Africa. The American journal of tropical medicine and hygiene 90: 546-52.
14.              Ramarokoto CE, Kildemoes AO, Randrianasolo BS, Ravoniarimbinina P, Ravaoalimalala VE, Leutscher P, Kjetland EF, Vennervald BJ, 2014. Eosinophil granule proteins ECP and EPX as markers for a potential early-stage inflammatory lesion in female genital schistosomiasis (FGS). PLoS Negl Trop Dis 8: e2974.
15.              Jourdan PM, Randrianasolo BS, Feldmeier H, Chitsulo L, Ravoniarimbinina P, Roald B, Kjetland EF, 2013. Pathologic mucosal blood vessels in active female genital schistosomiasis: new aspects of a neglected tropical disease. Int J Gynecol Pathol 32: 137-40.
16.              Hegertun IEA, Sulheim Gundersen KM, Kleppa E, Zulu SG, Gundersen SG, Taylor M, Kvalsvig JD, Kjetland EF, 2013. S. haematobium as a common cause of genital morbidity in girls: a cross-sectional study of children in South Africa. PLoS Negl Trop Dis 7: e2104.
17.              Ndeffo Mbah ML, Kjetland EF, Atkins KE, Poolman EM, Orenstein EW, Meyers LA, Townsend JP, Galvani AP, 2013. Cost-effectiveness of a community-based intervention for reducing the transmission of Schistosoma haematobium and HIV in Africa. Proc Natl Acad Sci U S A 110: 7952-7.
18.              Kjetland EF, Leutscher PD, Ndhlovu PD, 2012. A review of female genital schistosomiasis. Trends in Parasitology 28: 58-65.
19.              Jourdan PM, Holmen SD, Gundersen SG, Roald B, Kjetland EF, 2011. HIV target cells in Schistosoma haematobium-infected female genital mucosa. Am J Trop Med Hyg 85: 1060-4.
20.              Jourdan PM, Roald B, Poggensee G, Gundersen SG, Kjetland EF, 2011. Increased vascularity in cervicovaginal mucosa with Schistosoma haematobium infection. PLoS Negl Trop Dis 5: e1170.
21.              Berge ST, Kabatereine NB, Gundersen SG, Taylor M, Kvalsvig JD, Mkhize-Kwitshana Z, Jinabhai CC, Kjetland EF, 2011. Generic praziquantel in South Africa: The necessity for policy change to avail cheap, safe and efficacious schistosomiasis drugs to the poor, rural population Southern Afr J Epidemiol Infect 26: 22-25.
22.              Kjetland EF, Kurewa EN, Mduluza T, Midzi N, Gomo E, Friis H, Gundersen SG, Ndhlovu PD, 2010. The first community-based report on the effect of genital Schistosoma haematobium infection on female fertility. Fertility and Sterility 94: 1551-3.
23.              Kjetland EF, Ndhlovu PD, Mduluza T, Deschoolmeester V, Midzi N, Gomo E, Gwanzura L, Mason PR, Vermorken JB, Friis H, Gundersen SG, Baay MF, 2010. The effects of genital schistosoma haematobium on human papillomavirus and the development of cervical neoplasia after five years in a Zimbabwean population. Eur J Gynaecol Oncol 31: 169-73.
24.              Lillerud LE, Stuestoel VM, Hoel RE, Rukeba Z, Kjetland EF, 2010.Exploring the feasibility and possible efficacy of mass treatment and education of young females as schistosomiasis influences the HIV epidemic. Arch Gynecol Obstet 281: 455-60.
25.              Thomassen Morgas DE, Kvalsvig JD, Gundersen SG, Taylor M,Kjetland EF, 2010. Schistosomiasis and water-related practices in school girls in rural KwaZulu-Natal, South Africa. Southern Afr J Epidemiol Infect 25: 30-33.
26.              Kjetland EF, ten Hove RJ, Gomo E, Midzi N, Gwanzura L, Mason PR, Friis H, Verweij JJ, Gundersen SG, Ndhlovu PD, Mduluza T, van Lieshout L, 2009. Schistosomiasis PCR in vaginal lavage as an indicator of genital Schistosoma haematobium infection in rural Zimbabwean women. American Journal of Tropical Medicine and Hygiene 81.
27.              Hotez PJ, Fenwick A, Kjetland EF, 2009. Africa’s 32 cents solution for HIV/AIDS. PLoS Negl Trop Dis 3: e430.
28.              Kjetland EF, Kurewa EN, Ndhlovu PD, Gwanzura L, Mduluza T, Gomo E, Midzi N, Mason PR, Friis H, Gundersen SG, 2008. Female genital schistosomiasis – a differential diagnosis to sexually transmitted disease: Genital itch and vaginal discharge as indicators of genital S. haematobium morbidity in a cross-sectional study in endemic rural Zimbabwe. Tropical medicine and international health 13: 1509-17.
29.              Kjetland EF, Ndhlovu PD, Kurewa EN, Midzi N, Gomo E, Mduluza T, Friis H, Gundersen SG, 2008. Prevention of gynecologic contact bleeding and genital sandy patches by childhood anti-schistosomal treatment. American Journal of Tropical Medicine and Hygiene 79: 79-83.
30.              Jourdan PM, Laoussou P, Lybie A, Kjetland EF, 2008. Indicators of anaemia in under-fives with malaria at a hospital in northern Cameroon. West Afr J Med 27: 7-12.
31.              Ndhlovu PD, Mduluza T, Kjetland EF, Midzi N, Nyanga L, Gundersen SG, Friis H, Gomo E, 2007. Prevalence of urinary schistosomiasis and HIV in females living in a rural community of Zimbabwe: does age matter? Trans R Soc Trop Med Hyg 101: 433-438.
32.              Kjetland EF, Mduluza T, Ndhlovu PD, Gomo E, Gwanzura L, Midzi N, Mason P, Friis H, Gundersen SG, 2006. Genital schistosomiasis in women – a clinical in vivo 12-months’ study following treatment with praziquantel. Trans R Soc Trop Med Hyg 100: 740-752.
33.              Kjetland EF, Ndhlovu PD, Gomo E, Mduluza T, Midzi N, Gwanzura L, Mason PR, Sandvik L, Friis H, Gundersen SG, 2006. Association between genital schistosomiasis and HIV in rural Zimbabwean women. AIDS 20: 593-600.
34.              Clifford GM, Goncalves MA, Franceschi S, La Ruche G, Vuyst H, Hawes S, Mayaud P, Weiss H, Baay MF, Kjetland EF, Bollen L, Thomas D, Serraino D, Capobianchi M, Piselli P, Zaniratti S, Mistro AD, Lillo F, de Sanjose´ S, van Doornum G, Schuman P, Celentano D, Shah K, Klein R, Cu-Uvin S, Jamieson D, Moscicki AB, Hagensee M, Strickler H, Burk R, Anastos K, Minkoff H, Young M, Greenblatt R, Palefsky J, Levine A, Cohen M, Gange S, Levi JE, Volkow P, 2006. Human papillomavirus types among women infected with HIV: a meta-analysis. AIDS. 20: 2337-2344.
35.              Kjetland EF, Gwanzura L, Ndhlovu PD, Mduluza T, Gomo E, Mason PR, Midzi N, Friis H, Gundersen SG, 2005. Herpes simplex virus type 2 prevalence of epidemic proportions in rural Zimbabwean women: association with other sexually transmitted infections. Arch Gynecol Obstet 272: 67-73.
36.              Kjetland EF, Ndhlovu PD, Mduluza T, Gomo E, Gwanzura L, Mason PR, Kurewa EN, Midzi N, Friis H, Gundersen SG, 2005. Simple clinical manifestations of genital Schistosoma haematobium infection in rural Zimbabwean women. American Journal of Tropical Medicine and Hygiene 72: 311-319.
37.              Baay MF, Kjetland EF, Ndhlovu PD, Deschoolmeester V, Mduluza T, Gomo E, Friis H, Midzi N, Gwanzura L, Mason PR, Vermorken JB, Gundersen SG, 2004. Human papillomavirus in a rural community in Zimbabwe: the impact of HIV co-infection on HPV genotype distribution. J Med Virol 73: 481-5.
38.              Midzi N, Ndhlovu PD, Nyanga L, Kjetland EF, Reimert CM, Vennervald BJ, Gomo E, Mudenge G, Friis H, Gundersen SG, Mduluza T, 2003. Assessment of eosinophil cationic protein as a possible diagnostic marker for female genital schistosomiasis in women living in a Schistosoma haematobium endemic area. Parasite Immunol 25: 581-8.
39.              Kjetland EF, Poggensee G, Helling-Giese G, Richter J, Sjaastad A, Chitsulo L, Kumwenda N, Gundersen SG, Krantz I, Feldmeier H, 1996. Female genital schistosomiasis due to Schistosoma haematobium. Clinical and parasitological findings in women in rural Malawi. Acta Trop 62: 239-255.
40.              Helling-Giese G, Kjetland EF, Gundersen SG, Poggensee G, Richter J, Krantz I, Feldmeier H, 1996. Schistosomiasis in women: manifestations in the upper reproductive tract. Acta Trop 62: 225-38.
41.              Gundersen SG, Kjetland EF, Poggensee G, Helling-Giese G, Richter J, Chitsulo L, Koumwenda N, Krantz I, Feldmeier H, 1996. Urine reagent strips for diagnosis of schistosomiasis haematobium in women of fertile age. Acta Trop 62: 281-7.
42.              Richter J, Poggensee G, Kjetland EF, Helling-Giese G, Chitsulo L, Kumwenda N, Gundersen SG, Deelder AM, Reimert CM, Haas H, Krantz I, Feldmeier H, 1996. Reversibility of lower reproductive tract abnormalities in women with Schistosoma haematobium infection after treatment with praziquantel–an interim report. Acta Trop 62: 289-301.
43.              Helling-Giese G, Sjaastad A, Poggensee G, Kjetland EF, Richter J, Chitsulo L, Kumwenda N, Racz P, Roald B, Gundersen SG, Krantz I, Feldmeier H, 1996. Female genital schistosomiasis (FGS): relationship between gynecological and histopathological findings. Acta Trop 62: 257-67.
44.              Poggensee G, Reimert CM, Nilsson LA, Jamaly S, Sjastad A, Roald B, Kjetland EF, Helling-Giese G, Richter J, Chitsulo L, Kumwenda N, Gundersen SG, Krantz I, Feldmeier H, 1996. Diagnosis of female genital schistosomiasis by indirect disease markers: determination of eosinophil cationic protein, neopterin and IgA in vaginal fluid and swab eluates. Acta Trop 62: 269-280.
45.              Richter J, Poggensee G, Helling-Giese G, Kjetland EF, Chitsulo L, Koumenda N, Gundersen SG, Krantz I, Feldmeier H, 1995. Transabdominal ultrasound for the diagnosis of Schistosoma haematobium infection of the upper female genital tract: a preliminary report. Trans R Soc Trop Med Hyg 89: 500-501.
Popularised science 2013-2016 in the following
–          Forskning.no 2015
–          New York Times front page and pg 3, May 11th 2014
–          Le Monde (largest Francophone newspaper) pg 4, May 13 2014
–          Other newspapers 2014: at least 19 headlines e.g. India Times, The Times (South Africa), Post (Italy) etc.
–          Peer-reviewed oral/poster presentations at conferences in infectious diseases (9), gynaecology (2), HIV (2), and public health (3)
–          Talks to WHO Geneva (2) and at other international stakeholder meetings where WHO was present (7)
–       Arranged meetings at national levels where schistosomiasis is the main focus (12), and at district level in South Africa and Kenya (22), ward level (6), with medical doctors (47), nurses (11), headmasters and teachers (178), tribal leaders (2).


 
Research Support
Ongoing support
Norwegian Research Council – Clinical Research (# 213702, 2013 – 2015)
Role: Principal investigator together with Professor Myra Taylor in exploring the effect of schistosomiasis on HIV in females, clinically and ethically responsible, project manager .
Institution (s): Oslo University Hospital (OUH), Norway. University of KwaZulu-Natal (UKZN), South Africa. Imperial College, UK. Leiden University Medical Centre, The Netherlands. University of Antwerp, Belgium. University of Copenhagen (UCPH), Denmark. Sorlandet Hospital and University of Agder, Norway.
 
European Union FP7-PEOPLE-IRSES (# 269245, 2011 – 2016)
Role: Coordinator. Principal investigator.
 
Bill and Melinda Gates Foundation (# OPPGH5344, 2009 – 2016)
Role: Principal investigator together with Professor Myra Taylor in exploring schistosomiasis in adolescent females in a prospective randomized controlled trial, clinically and ethically responsible. Through UCPH.
 
South-Eastern Regional Health Authority, Norway & VIRUUS Norway (2011 – 2024)
Role: PI Eyrun Kjetland, OUH
Completed relevant projects
Bill and Melinda Gates Foundation (# OPPGH5344) field work in Madagascar (2010)
Role: PI together with Pascaline in a case definition study, clinically and ethically responsible. Through UCPH
 
WHO / TDR field work in Zimbabwe (1998  – 2003)
Role: Co-PI, Project clinician, laboratory work, community liaison, resulted in 12 publications. PI: Dr. Patricia Ndhlovu 
Institution (s): OUH, Norway. Blair Research Institute, Zimbabwe.
 
WHO / TDR field work in Malawi (1994 – 1996)
Role: Project clinician, community liaison, resulted in 7 publications. PI: Professor Hermann Feldmeier
Institution (s): OUH, Norway. Mangochi Hospital, Malawi, Freie Universität, Berlin, Germany, WHO. Department of Anatomic Pathology, OUH, Norway.
 
South-Eastern Regional Health Authority, Norway & VIRUUS Norway (2011 – 2013)

Role: Networking in organizations, PI Svein Gunnar Gundersen, Sorlandet Hospital / co-PI Eyrun Kjetland, OUH