Prof Indres Moodley
Prof Indres Moodley
+27 (0)31 260 4497
Health Outcomes 7 Health Economics
Director, Health Outcomes Research Unit
Professor Indres Moodley, is the Director of the Health Outcomes Research Unit in the Department of Public Health. His contribution to teaching and research is as follows:
1. Education and training
He is involved in the teaching and examination of the module in Health Economics and Healthcare Financing for MPH students. He also supervises first year students of the module “Making a Difference”. He is also guest lecturer in Healthcare Financing for the SIT Programme funded by USAID.
2. Research and development He contributes to research support (protocol development and conducting research) for MPH. and Ph.D students and Registrars in Health Economics and Health Economics Research. Prior to joining the Discipline of Public Health Medicine, he was Chair and Head of Department of Pharmacy & Pharmacology at the Medical School, University of the Witwatersrand for 5 years and Director of Health Economics at the Pharmacia Corporation, South Africa. He was involved in a variety of projects in health systems with the National Department of Health, also in Gauteng and KwaZulu-Natal province where he has conducted analyses on costs various models of care, health services in the public sector for tuberculosis, and HIV/AIDS, district health systems and the National Health Insurance. He has developed expertise in conducting an analysis for the national health accounts. His research involvement is highlighted on the attached CV.
3. Academic ontribution to the School
He is well known both nationally and internationally for his contributions to clinical, scientific and health related research. He has served on statutory bodies such as the South African Pharmacy Council and the Minister of Health’s Pharmaceutical Pricing Committee. He is also special advisor to WHO/TDR on the application of health related research to improve equity and access to healthcare. He was appointed to the Board of the Medical Research Council. He works in collaboration with a number of research Centres such as the Health Economics Unit at UCT and the Africa Centre. He works in consultation with the Departments of Health, Trade and Industry and Science and Technology where he is involved in fostering the biomedical collaboration of traditional practitioners with the allopathic health systems. He has been awarded a number of national and provincial tenders in the public healthcare sector and is consulted by a number of pharmaceutical companies and other institutions.
List of Publications
Respiratory Pharmacology and Medicine
MOOLDEY I and MONGAR J.L. (1981) IgG receptors on the mast cell. Agents Actions, 11, 77-83.
MOODLEY I and MONGAR J.L. (1981) Dextran receptors on rat mast cells. Clin.Allergy, 11, 198-199.
MOODLEY I.and DAVIES R.J. (1981) Inhibition and stimulation of mediator release from human leucocytes and human lung by Ketotifen. Clin.Sci. ,62, 13-14.
MOODLEY I., MONGAR J.L. and FOREMAN J.C. (1982) Histamine release induced by dextran : the nature of the dextran receptor. Eur.J.Pharmacol., 83(1-2), 69-81.
MOODLEY I.and DAVIES R.J. (1982) The mechanism of action of Ketotifen-induced histamine release from human peripheral leucocytes. Int. Arch. Allergy Appl. Immunol.,68(2), 176-178.
MORGAN D.J., PHILLIPS M.J., MOODLEY I., ELLIOT E.V. and DAVIES R.J. (1982) Histamine, neutrophil chemotactic factor and circulating basophil levels in asthmatic and control subjects. Clin. Allergy, 12 (Suppl) 29-37.
DAVIES R.J.and MOODLEY I. (1982) Antiallergic compounds. Pharmacol. Ther., 17, 279-297.
MORGAN D.J., MOODLEY I., PHILLIPS M.J. and DAVIES R.J. (1983) Plasma histamine in asthmatic and control subjects following exercise : influence of circulating basophils and different assay techniques. Thorax, 38(10), 771-777.
PHILLIPS M.J., MEYRICK THOMAS R.H., MOODLEY I. and DAVIES R.J. (1983) A compararison of the in vivo effects of ketotifen, clemastine, chlorphenramine and sodium cromoglycate on histamine and allergen induced weals in human skin. Br. J. clin. Pharamac. 15, 277-286.
CUNDELL D.R., MOODLEY I.and DAVIES R.J. (1984) Properties of a high molecular weight neutrophil chemotactic factor, possibly derived from mast cells : evidence for chemokinetic rather than chemotactic activity. Agents and Actions, 14, 484-487.
MOODLEY I., ZHONG N.S., MORGAN D.J.R. and DAVIES R.J. (1984) A comparison of the available methods for the measurement of histamine in sputum. Clin. Allergy, 14(2), 153-163.
MORGAN D.J.R., MOODLEY I., CUNDELL D.R., SHEINMAN B.D., SMART W. and DAVIES R.J. (1985) Circulating histamine and neutrophil chemotactic activity during allergen-induced asthma : the effect of inhaled antihistamines and anti-allergic compounds. Clin.Sci., 69(1), 63-69.
MOODLEY I. and STUTTLE A. (1987) Evidence for a dual pathway in platelet activating factor-induced aggregation of rat polymorphonuclear leucocytes. Prostaglandins,33, 253-256.
MOODLEY I; FOSTER M (1989) Effects of disease modifying anti-rheumatic agents on class II antigen expression. Agents and actions 1989;26(1-2):160-2
MOODLEY,I., GROUHEL,A., LELIEVRE,V. and JUNIEN,J.L. (1990) Anti-inflammatory properties of tixocortol 17-butyrate, 21-butyrate (JO 1222) a novel, locally acting corticosteroid. J. Lipid Mediators, 3(1), 51-70.
LAGENTE, V., MOODLEY,I., PERRIN,S., MOTTIN, G. and JUNIEN, J.L. (1994). Effects of isozyme selective phosphodiesterase inhibitors on eosinophil infiltration in the guinea pig lung. European Journal of Pharmacology, 255, 253-256.
LAGENTE, V., PRUNIAUX, M-P., JUNIEN, J.L.and MOODLEY,I. (1995). Modulation of Cytokine-Induced Eosinophil Infiltration by Phosphodiesterase Inhibitors. American Journal of Respiratory and Critical Care Medicine, 151, 1720-1724
HICHAMI, A., BOICHOT, E., GERMAIN, N., LEGRAND, A., MOODLEY, I. and LAGENTE, V. (1995). Involvement of cyclic AMP in the inhibitory effects of phosphodiesterase IV inhibitors on arachidonate release from mononuclear cells. Eur.J. Pharmacol. (Mol Pharmacol). 291, 91-97.
BANNER, K.H., BERTIN, B., MOODLEY, I., and PAGE, C.P. (1996). Effect of Isoenzyme Selective Phosphodiesterase Inhibitors on the Proliferation of Murine Thymus and Spleen Cell. Pulmonary Pharmacology, 9, 35-41
STILLINGS, M., HAVLIK,I., CHETTY,M., CLINTON, C., SCHALL, R., MOODLEY,I., MUIR,N. and LITTLE, S. (2000). Comparison of the Pharmacokinetic Profiles of Soluble Aspirin and Solid Paracetamol Tablets in Fed and Fasted Volunteers. Curr Med Res Opin. 16(2) ,115-124
PASCAL Y; ANDRIANJARA C R; AUCLAIR E; AVENEL N; BERTIN B; CALVET A; FÉRU F; LARDON S; MOODLEY I; OUAGUED M; PAYNE A; PRUNIAUX M P; SZILAGYI C (2000) Synthesis and structure-activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: novel PDE4 inhibitors. Bioorganic & medicinal chemistry letters 2000;10(1):35-8.
AMOD,F., MOODLEY, I., PEER, A.K.C., SUNDERLAND,J., LOVERING, A., WOOTTON, M., NAVDI, S. and VAWDA,F. (2005). Ventriculitis due to hetero strain of vancomycin intermediateStaphylococcus aureaus (hVISA): successful treatment with linezolid in combination with intraventricular vancomycin. J Infection. 50 (3), 252-257.
PEROVIC, O., KOORNHOF, H., BLACK, V., MOODLEY I, DUSE A. and GALPIN, J. (2006).Staphylococcus aureus bacteraemia at two academic hospitals in Johannesburg, South Africa. South African Medical Journal. 96(8) 714-717
MOODLEY, I. (2006) Analysis of a medical aid administrator database for costs and utilisation of benefits by patients claiming for lipid-lowering agents Cardiovascular Journal of South Africa, (17, Issue 3), 140-145
MOODLEY I; BUBB M and MSOMI N (2007) Concept paper: establishment of a diagnostics platform for South Africa. African journal of medicine and medical sciences 2007;36 Suppl():19-22.
GQALENI, N, MOODLEY I, KRUGER H,, NTULI A and MCLEOD H (2008) Traditional and Complementary Medicine South Africa Health Review 174-185
MOODLEY I (2008) Review of the cardiovascular safety of COXIBs compared to NSAIDS.Cardiovascular journal of Africa 19(2):102-7.
MOODLEY I.and FOSTER M. (1989) Effects of disease modifying anti-rheumatic agents on class II antigen expression. Agents and Actions,26, 160-162.
MOODLEY, I., SOTSIOS, Y. and BERTIN, B. (1995). Modulation of Oxazolone-Induced Hypersensitivity in Mice by Selective PDE Inhibitors. Mediators of Inflammation, 4, 112-116.
MOODLEY, I and HIRSCH,G (2001) Celecoxib–a rational alternative to NSAIDs. S Afr Med J. 2001 Jan;91(1):36-40. Review
MOODLEY I and HEYNS C F on behalf of the Committee: de Jong P R, de Wet G H, Ramphal S R, Rienhardt G W, Smith T H, Snyman J, Finkelstein M, Fockema M, Hammann E, McDonald L, Noble J, Borchers T, Breytenbach I H, Duvenhage F, Fourie T J, Harden P J, Hoosen G M, Levinson I P, Smart D O, Viljoen I M and van Wyk F J. (2002). Guidelines for General Practitioners for the Treatment of Urinary Incontinence and Overactive Bladder. Insight 1,3-9.
DANCKWERTS, M.P., J.G. VAN DER WATT. and MOODLEY, I. (1996). The Effect of processing variables on the release of ibuprofen and caffeine from controlled release non-swellable core-in-cup compressed tablets. Drug Development and Industrial Pharmacy. 22(7),681-687.
DANCKWERTS, M.P., J.G. VAN DER WATT. and MOODLEY, I. (1997). Zero-order release of theophylline from a novel core-in-cup tablet in simulated gastric and intestinal fluid. Drug Development and Industrial Pharmacy. 24(2),163-168.
DANCKWERTS, M.P., J.G. VAN DER WATT. and MOODLEY, I. (1998). Pharmcokinetic Evaluation in Dogs of Theophylline in a Novel Zero-Order Release Core-in Cup Tablet.Biopharm. Drug Dispos. 19, 517-522.
GRAHAM,B. and MOODLEY,I.(1999). Economic Evaluation of Low Molecular Weight Heparin in the Management of Patients with Unstable Coronary Artery Disease. . Cardiovascular Journal of Southern Africa (SAMJ). 89, C20-C23.
ANDERSON,A.N., WESSELS,F, MOODLEY,I, and KROPMAN, K (2000). AT1 receptor blockers–cost-effectiveness within the South African context. S Afr Med J. 90(5), :494-498
ANDERSON,A.N., MOODLEY,I, and KROPMAN, K (2000). A South African pharmacoeconomic anaylsis of the Acute Infarction Ramipril Efficacy (AIRE) study. Cardiovascular Journal of Southern Africa (SAMJ). 11, C89-C94.
ANDERSON, A.N., WESSELS, F., MOODLEY, I and KROPMAN, K. (2000) AT1 receptor blockers–cost-effectiveness within the South African context. S Afr Med J;90(5),494-498
MOODLEY, I. (2006) Analysis of a Medical Aid Administrator Database for Costs and Utilisation of Benefits by Patients Claiming for Lipid Lowering Agents. Cardiovascular Journal of South Africa, 17( 3) 140-145
MOODLEY I, RAYNER B,and SINGH D (2006) Losartan appears cost-effective for reducing stroke in people with hypertension and left ventricular hypertrophy Evidence-based Cardiovascular Medicine 10(2), 94-95
VELLA,V., DLAMINI,S., GOVENDER,T., TAYLOR, M, MOODLEY.I., DAVID,V. and JINABHAI, Retrospective Study on the Critical Factors for Retaining Patients on Antiretroviral Therapy in KwaZulu-Natal,South Africa. J Acquir Immune Defic Syndr 2010;55:109–116
C VELLA,V., GOVENDER,T., DLAMINI,S., , MOODLEY.I., DAVID,V ., TAYLOR, M. and JINABHAI,C Cost-effectiveness of staff and workload profiles in retaining patients on antiretroviral therapy in KwaZulu-Natal, South Africa. AIDS Care, DOI:10.1080/09540121.2011.554517:http://dx.doi.org/10.1080/09540121.2011.554517
MOODLEY, S and MOODLEY,I. A Comparative Cost Analysis of Picture Archiving and Communications Systems
(PACS) with Conventional Radiology in the Private Sector . In press
MOODLEY I, KISTNASAMY B,VAN DEN HEEVER A, LALLOO U, PILLAY P, PILLAY S, MAHOMED O AND REIPRICH G, HEAIDS, 2010. Funding models for the provision of HIV and AIDS services to staff and students at Higher Education institutions in South Africa. Pretoria: Higher Education South Africawww.heaids.org.za
MOODLEY I, KISTNASAMY B,VAN DEN HEEVER A, LALOO U AND REIPRICH G, Development of sustainable funding model(s) and mechanisms(s) with respect to a comprehensive HIV and AIDS programme in the Higher Education sector HEAIDS, 2010.
GQALENI, N., MAKHATHINI, M, MBATHA, N. BUTHELEZI,T., MKHIZE ,T., DAVIDS, V., NAIDOO,S, and MOODLEY,I Education and Development of Traditional Health Practitioners in isiZulu to Promote their Collaboration with Public Health Care Workers. Alternation 17,1 (2010) 295 – 311 ISSN 1023-1757.
GQALENI, N., MAKHATHINI, M.E., MBANJWA, N., MBATHA, N., NKOMO-GWALA, B.L., BUTHELEZI, T., DUBE, T., MAHLANGENI, N., MKHIZE, T., MOODLEY, I., AND NAIDOO, S.S. 2009. Education and Development of Traditional Health Practitioners in isiZulu to promote their collaboration with Public Health Care Workers. Alternation (Journal of the Centre for the study of Southern African Literature & Languages), Alternation 17,1 (2010) 295 – 311 ISSN 1023-1757.
NGCOBO, M., NKALA, B., MOODLEY, I, AND * GQALENI, N. Recommendations for the Development of Regulatory Guidelines for registration of Traditional Medicines In South Africa. Afr J Tradit Complement Altern Med. (2012) 9(1):00-00
MOODLEY, I, TATHIAH, N VICTORIA MUBAIWA, V, DENNY,L (2013). High uptake of Gardasil™ vaccine among 9-12 year old schoolgirls participating in a HPV vaccination demonstration project in KwaZulu-Natal, South Africa Afr Med J 2013;103(5):318-321. DOI:10.7196/SAMJ.6414
TATHIAH, N., MOODLEY, I, TAYLOR, M., VICTORIA MUBAIWA, V, South Africa in Nutritional Transition: Overweight, obesity, underweight and stunting in female primary school learners in rural KwaZulu-Natal, South Africa . In press SAMJ
Non Peer-reviewed Publications
MOODLEY, I (1997). Proposed Changes to Regulations on Dispensing of Medicines by Medical Practitioners . The Leech, Journal of the Medical and Allied Medical Students of the University of the Witwatersrand, 66(1), 4-8
MOODLEY, I (1997) Influence of Health Care Reform on Academic Training in the Health Sciences. The Leech, Journal of the Medical and Allied Medical Students of the University of the Witwatersrand, 66(2), 24-27.
Letters to Editors
MOODLEY, I and HIRSCH, G (2001). A rational alternative to NSAIDs. S Afr Med J 91, 36-40
MOODLEY, I. (2001 ). Celecoxib – The Debate Rages On . S Afr Med J 91, 445-446
MOODLEY I and ALLY M.M.T.M. (2002) Response to “ To prescribe or not to prescribe” Editorial and CME by R. Jobson, SA Family Practice 2002, 25(3): 20-24. Accepted for publication
1995: Novel and selective PDE IV inhibitors – Worldwide Patent Calvet et al. – January, 1992 – 5082937
1997: Novel formulation for combination anti-tuberculosis drugs
PROJECTS AND REPORTS
Respiratory Pharmacology and Medicine
MONGAR J.L and MOODLEY I. (1981) Dextran and histamine secretion from rat mast cells : effect of glucose and low molecular weight glucose polymers. Br.J.Pharmac. 73, 206P.
PHILLIPS M.J., THOMAS R.M., MOODLEY I. and DAVIES R.J. (1981) A study of the effects of Ketotifen on histamine and allergen induced wheals in human skin. Clin.Sci., 62, 52P.
MOODLEY I., DANKS. J., MORGAN D.J.R. and DAVIES R.J. (1982) Contribution of basophils to changes in plasma histamine levels after exercise testing. Clin. Sci., 63, 76P.
MOODLEY,I., GROUHEL,A. CHANIONE,F.and JUNIEN,J.L. (1990) Effect of Tixocortol BP (JO 1222), a Novel Locally Acting Corticosteroid, on antigen-induced bronchoconstriction and metabolism in the rat. IUPHAR Satellite Meeting (New Drugs for Asthma), 10-11th July, 1990,Davos Switzerland.
GROUHEL, A., BOUTROU, C., MOODLEY, I. and JUNIEN,J.L. (1990). Effect of a novel locally acting corticosteroid, Butixicort propionate (JO1222) on monoarticular arthritis in the rabbit. IUPHAR Satellite Meeting (Drugs in Inflammation), 28-29th June, 1990, Noordwijk, The Netherlands.
MOODLEY,I., PLANQOUIS, J.M. and JUNIEN, J.L. (1991). Characterisation of mu receptor subtypes involved in non-cholinergic-non-adrenergic (NANC) bronchoconstriction. Annual Conference of BSACI, 4-6 September, 1991, London.
LAGENTE, V., MOODLEY,I., PERRIN,S., MOTTIN, G. and JUNIEN, J.L. (1994).
Effects of isozyme selective phosphodiesterase inhibitors and theophylline on eosinophil infiltration in the guinea pig lung. British Pharmacological Society, 5-7 January 1994,London.
BANNER, K.H., BERTIN, B., MOODLEY, I., and PAGE, C.P. (1994). Differential effects of the Type IV phosphodiesterase (PDE) inhibitor, rolipram on the proliferation of mouse T and B lymphocytes. IUPHAR 94, 12th International Congress of Pharmacology, 24-30th July, 1994, Montreal, Canada.
MOODLEY, I., MOTTIN, G., PERRIN, S., JUNIEN, J.L. and LAGENTE, V. (1994). Effects of selective phosphodiesterase inhibitors and theophylline on antigen-induced microvascular leakage in the guinea pig trachea. 1994 American Lung Association/American Thoracic Society International Conference. 21-25 May 1994. Boston, Massachusetts. American Journal of Respiratory and Critical Medicine, 149 (4), A328.
LAGENTE, V., PERRIN, S., MOTTIN, G., JUNIEN, J.L. and MOODLEY, I. (1994). Type IV selective phosphodiesterase inhibitors reduce eosinophil infiltration in the guinea pig lung induced by antigen, platelet activating factor and interleukin 5. trachea. 1994 American Lung Association/American Thoracic Society International Conference. 21-25 May 1994. Boston, Massachusetts. American Journal of Respiratory and Critical Medicine, 149 (4), A762.
LAGENTE, V., HICHAMI, S., BOICHOT, E., GERMAIN, N. and MOODLEY, I. (1995). Investigation of the role of cyclic AMP on the inhibitory effects of selective phosphodiesterase inhibitors on arachidonic acid release from mononuclear cells. American Lung Association/American Thoracic Society International Conference. 21-21-24 May 1995. Seattle, Washington. American Journal of Respiratory and Critical Medicine.
PLANQUOIS, J.M., RUFFIN-MORIN Y. and MOODLEY I. (1995). potentiation of relaxant effects of selective phosphodiesterase inhibitors on guinea-pig trachealis by threshold concentrations of salbutamol. French Pharmacol. Society
GOUS, H., GOUS, A.G.S., MOKCHACHANE,M., STRACHAN,S., SHINGWENYANA, N . and MOODLEY, I. (1977). Single -dose pharmacokinetics of piperacillin and tazobactam in neonates. South African Hospital and Institutional Pharmacists Conference, 20-22 March 1997.
MOODLEY, I., SHINGWENYANA, N AND RICHARDS, G. (1999). Modulation of intracellular IL4 and IFNg in atopic by dexamethasone and salbutamol. Chest in the New Millenium, 15th SA Pulmonary Congress. The Wild Coast Sun, Port Edward, KwaZulu-Natal, 21 – 25 March 1999.
PEROVIC,O., KOORNHOF,H., FERRAZ,V., MOODLEY,I., DUSE,A., GALPIN,J. (2004). Staphylococcus aureus bacteraemia at two academic hospitals in Johannesburg, South Africa. 44th ICAAC, Washington DC. 30 October to 2 November 2004 Poster No.K-754.
Inflammation and CNS Pharmacology
MOODLEY,I., GROUHEL,A., WITKO,V. and JUNIEN,J.L. (1990) Effects of PCP and sigma ligands on NMDA- and DTG- induced convulsions in mice. Brit.J.Pharmacol.100, 380P.
MOODLEY,I., GROUHEL,A. and JUNIEN,J.L. (1990) Effect of a novel locally acting corticosteroid, JO 1222 on monoarticular arthritis in the rabbit. International Congress on Inflammation, Barcelona, Spain.
Natural Product Chemistry and Pharmacology
ROHITLALL, N., ISMAIL, I, MOODLEY, I, HUTCHINGS, A and GOLDRING, J.P.D. (1997).Traditional medicines and antimalarial drugs disrupt Plasmodium falciparum rosettes. South African Biochemical and Molecular Biological Society Meeting.
HUTCHINGS, A., MOODLEY,I. AND NZIMA D. (1977).Coming together of traditional healers and allopathic medicine. Seventh Natural Products Research Network for Eastern and Central Africa (NAPRECA) Symposium on African Genetic Resources for Development of Pharmaceuticals and Agrochemicals. 17-22 August, 1997. Silver Sands Hotel, Dar es Salaam, Tanzania.
I. MOODLEY. (1997). The Ethical Use of Indigenous South African Plants and other Natural Products for Pharmaceutical Research. Third NABSA Sub-Regional Symposium on Natural Products. Department of Chemistry, University of Botswana, Botswana. 10-11 October 1997
DANCKWERTS, M.P., VAN DER WATT, J.G. and MOODLEY, I. (1996). In vitro and in vivo zero order release of theophylline from core-in-cup tablets. The first International Conference on Pharmaceutical and Pharmacological Sciences . Johannesburg 22-25 September 1996.
MODI, D., PRESBURY, D., ANDERSON, N., KROPMAN, K., MOODLEY, I and WESSELS, F. (1999). Exploratory Quality of Life Study in Acne Patients. Congress of the Dermatological Society of South Africa. Cape Town 22-24 September 1999.
TATHIAH, N., MOODLEY, I, TAYLOR, M., VICTORIA MUBAIWA, V, Overweight, obesity, underweight and stunting in female primary school learners in Zululand, South Africa – evidence for a nutritional transition. PASA Conference. 2013 Cape Town